DAO Enzyme Supplement

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What exactly is DAO? Explanation of Diamine Oxidase Supplements.

What Is DAO and How Does It Work?

Diamine oxidase (DAO) is a digestive enzyme that is produced in your kidneys, thymus, and the lining of your intestine.

Its main job is to break down any excess histamine in your system.

Histamine is a naturally occurring substance that aids in the regulation of digestive, nervous, and immune functions.

If you've ever had an allergic reaction, you're probably familiar with symptoms like nasal congestion, itchy skin, headaches, and sneezing that are caused by high histamine levels.

Histamine can also be consumed through food. It's found in a variety of foods, particularly those that have been aged, cured, or fermented, such as cheese, wine, pickles, and smoked meats.

To avoid histamine-induced symptoms, DAO keeps histamine levels in a healthy range.


What Is DAO, and How Does It Work?

Diamine oxidase (DAO) is a digestive enzyme that is produced in your kidneys, thymus, and the lining of your intestine.

Its main job is to break down any excess histamine in your system.

Histamine is a naturally occurring substance that aids in the regulation of digestive, nervous, and immune functions.

If you've ever had an allergic reaction, you're probably familiar with symptoms like nasal congestion, itchy skin, headaches, and sneezing that are caused by high histamine levels.

Histamine can also be consumed through food. It's found in a variety of foods, particularly those that have been aged, cured, or fermented, such as cheese, wine, pickles, and smoked meats.

To avoid histamine-induced symptoms, DAO keeps histamine levels in a healthy range.

  • congestion in the nose
  • headaches
  • Hives, rashes, and itchy skin
  • sneezing
  • Asthma and breathing problems
  • erratic heartbeat (arrhythmia)
  • diarrhoea, stomach aches, and gastrointestinal distress
  • vomiting and nausea
  • blood pressure that is too low (hypotension)

Genetic mutations, alcohol use, certain medications, intestinal bacterial overgrowth, and eating large amounts of histamine-containing foods are all possible causes of decreased DAO activity or overproduction of histamine.

Histamine intolerance is difficult to diagnose because the symptoms are ambiguous and overlap with those of other illnesses.

If you suspect you have histamine intolerance, seek the advice of a qualified healthcare provider to thoroughly investigate the causes of your symptoms before diagnosing or treating yourself.


DAO Supplements' Potential Benefits

Histamine intolerance and DAO deficiency can be treated in a variety of ways, including by taking DAO supplements.

Early research suggests that DAO supplements can help with headaches, skin rashes, and digestive issues associated with histamine intolerance.


Symptoms of the Digestive System

After taking 4.2 mg of DAO twice daily for two weeks, 93 percent of 14 people with histamine intolerance and symptoms like abdominal pain, bloating, or diarrhea reported relief from at least one digestive symptom.


Migraine Headaches and Migraine Attacks

In a one-month study of 100 people with previously diagnosed DAO deficiency, daily DAO supplementation resulted in a 23% reduction in the duration of migraine attacks when compared to the placebo group.


Rash on the Skin

In a 30-day study of 20 people with chronic spontaneous urticaria (skin rash) and DAO deficiency, those who took the supplement twice daily saw significant improvement in their symptoms and needed less antihistamine medication (5Trusted Source).

Although these studies suggest that supplementing with DAO may eliminate or improve deficiency symptoms, there's no guarantee that it will work for everyone.

Finally, more research is required before definitive conclusions can be drawn.


Dosage Recommendations and Safety Precautions

In studies on DAO supplements, no negative health effects have been reported.

However, because research on this supplement is still limited, a clear consensus on dosing has yet to be reached.

The majority of studies used 4.2 mg of DAO twice or three times daily, just before meals.

As a result, similar dosages are probably safe for the majority of people — but that doesn't mean they're completely risk-free.'

Nutritional supplements are not regulated in some countries, such as the United States. As a result, check to see if your product has been tested for purity and quality by a third party, such as the United States Pharmacopeia Convention (USP).

Before adding a new supplement to your diet, always check with your doctor first.


Final Thoughts

DAO supplements will not cure histamine intolerance or deficiency, but they may help to alleviate symptoms by breaking down histamine from external sources such as food and beverages.

Though current studies report no adverse effects, more research is needed to determine their effectiveness, safety, and dosage.

Before adding any new supplement or medication to your wellness routine, talk to a qualified healthcare provider.


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