Benefits Side Effects And Dosage Of DIM Supplements

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DIM Supplements: What Are They? Advantages and More.

When you eat cruciferous vegetables like broccoli or Brussels sprouts, a compound called diindolylmethane (DIM) is formed.

DIM appears to have an effect on estrogen levels in the body, according to research.

As a result, DIM supplements are becoming more popular as a treatment for a variety of hormone-related conditions, such as acne, menopause symptoms, prostate issues, and certain types of cancer.

Still, you might wonder if these applications are supported by scientific evidence.

This article gives a thorough overview of DIM supplements, including their advantages and disadvantages.


DIM supplements are what they sound like.

Your stomach acid breaks down a compound called indole-3-carbinol to produce a new compound called DIM when you eat cruciferous vegetables.

Surprisingly, observational studies link a high intake of cruciferous vegetables to a lower risk of certain cancers, such as breast and prostate cancer. While the exact mechanism is unknown, it is thought that indole-3-carbinol plays a role.

DIM is thought to help balance estrogen levels in the body, despite the fact that research on it is still limited.

DIM, in particular, may stimulate the production of 2-hydroxyestrone, a less potent but more beneficial form of estrogen.

It may also help to mitigate the effects of a stronger form known as 16 alpha-hydroxyestrone, which has been linked to weight gain and an increased risk of certain cancers, such as breast and prostate cancers.

DIM has also been shown to inhibit aromatase, an enzyme that converts testosterone into estrogen.

While cruciferous vegetables are the most common source of DIM, you'd have to eat several servings per day to reap the benefits of this compound.

As a result, people seeking a concentrated dose in the form of a DIM supplement may be seeking to treat a specific condition such as acne or prostate issues.


DIM supplement uses and potential benefits

DIM supplements are being researched for their cancer-fighting properties. They're also used to prevent prostate enlargement, treat acne, help with weight loss, and alleviate PMS and menopause symptoms.

While these advantages are promising, there is a scarcity of research on DIM's efficacy and long-term safety in humans.


It's possible that it has anticancer properties.

DIM supplements may help prevent the growth and spread of breast cancer cells, according to test-tube and animal studies. Human studies, on the other hand, are limited.

Over the course of a year, 130 women with breast cancer who were taking tamoxifen were given either a placebo or 150 mg of DIM twice a day. The ratio of two types of estrogen — 2-hydroxyestrone and 16-hydrozyestrone — was significantly improved after taking DIM supplements.

Increasing the ratio of 2-hydrozyestrone to 16-hydrozyestrone may reduce breast cancer risk and have anti-tumor effects, according to research.

A 30-day study found that taking 108 mg of DIM per day resulted in beneficial changes in estrogen levels in 19 postmenopausal women with early-stage breast cancer.

DIM appears to protect against ovarian, prostate, and colon cancers in both test tubes and animals. Nonetheless, human studies are required.

DIM was found to help prevent cervical cancer in a mouse study. However, taking 150 mg of DIM per day for six months had no effect on cervical cell changes in 551 women with abnormalities.


It's possible that it can help prevent prostate problems.

DIM supplements may protect against prostate cancer and enlargement.

In fact, it may aid in the treatment of prostatic intraepithelial neoplasia (PIN), a condition marked by the growth of prostate cells and thought to be a precursor to prostate cancer.

21 men with high-grade PIN were given either a placebo or 900 mg of DIM per day for a 12-month study. DIM significantly improved prostate health and PIN in those who received it.

DIM appears to help fight prostate cancer in both test tubes and animals. More human research is still required.


Weight loss may be aided.

DIM supplements may help with weight loss because estrogen is involved in fat accumulation regulation. However, there is no human research to back this up.

Regardless, studies show that an estrogen imbalance — either too much or too little — increases the risk of weight gain in both men and women.

DIM supplements may also help to break down fat and prevent fat cell formation.

In one study, 23 mg of DIM per pound (50 mg per kg) of body weight significantly reduced the formation of new fat cells in mice fed a high-fat diet.

Keep in mind that human research is required.


Other potential applications and advantages

DIM supplements are said to help with a variety of hormone-related issues. It's important to remember, however, that research on all of these effects is lacking.

  • Acne-fighting properties. Hormonal acne is sometimes treated with DIM supplements. However, there is currently no evidence to support this practice.
  • Hot flashes may be lessened. Hormonal changes are most likely to blame for hot flashes during menopause. While DIM supplements are used to reduce hot flashes, there is no evidence that they are effective.
  • PMS symptoms may be alleviated. Monthly changes in estrogen levels are thought to be the cause of PMS symptoms. Again, some people take DIM supplements to help with symptoms, but there is no scientific evidence that they work.
  • In men, it may help to correct estrogen imbalances. Breast growth, erectile dysfunction, and infertility have all been linked to high estrogen levels in men. DIM supplements may be beneficial, but they have yet to be tested in humans.


Precautions and possible side effects

Little is known about the long-term safety and side effects of DIM supplements due to a lack of human research.

DIM supplements are not toxic or have serious side effects, according to current human research. Darkening of the urine, increased bowel movements, headaches, and gas are the most common side effects.

Nausea, vomiting, diarrhea, and skin rash are some of the less common side effects.

DIM supplements may affect people with hormone-sensitive cancers or those on hormone therapy because they interact with estrogen levels. DIM supplements should not be taken by such people unless they are under the care of a medical professional.

It's important to talk to your doctor before taking these supplements, regardless of your medical history.


What dosage of DIM should you take?

DIM dosages are unknown due to a scarcity of research.

Doses in human research typically range from 108 to 900 mg per day, though these studies were limited to cancer and prostate enlargement treatments.

However, a study of 24 healthy people found that while DIM doses up to 200 mg were well tolerated and had no side effects, one person experienced nausea, headache, and vomiting after taking a 300-mg dose, suggesting that higher doses may be associated with negative side effects.

Weight loss and acne treatment are two other uses of DIM supplements that have not been studied in humans.

As a result, it's best to consult with your doctor for personalized dosage recommendations based on your intended use.


Last but not least

When you consume cruciferous vegetables, your body produces DIM. It's also available in a concentrated form as a supplement.

DIM may help treat a variety of conditions, including hormone-sensitive cancers and prostate issues, because it affects estrogen levels.

Nonetheless, more research is needed, especially for uses such as acne, weight loss, and PMS symptoms, which aren't currently supported by human research.

As a result, you should consult your doctor before taking DIM supplements.

No matter how effective DIM is, eating more cruciferous vegetables is always a good idea. After all, vegetables like broccoli and kale are high in fiber, antioxidants, vitamins, and minerals, among other nutrients. As a result, it's best to speak with your doctor to get personalized dosage recommendations based on your specific needs.

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