Best Supplements For Depression And Anxiety

+ Font Size -

11 Medicinal Plants and Supplements to Fight Depression

Depression is a mental illness that affects about 17 million persons in the United States alone. However, the true figure is likely to be substantially higher because many people suffering from depression do not seek treatment for a variety of reasons.

The five classes of depressive illnesses are shown below, and they all share characteristics such as sorrow, irritable mood, a sense of emptiness, and cognitive impairments that impair functioning:

  • major depressive disorder (MDD)
  • disruptive mood dysregulation disorder
  • persistent depressive disorder
  • premenstrual dysphoric disorder
  • depressive disorder due to another medical condition

Medication and psychotherapy are used to treat depressive disorders. Furthermore, lifestyle adjustments, such as dietary changes and the use of specific supplements, may aid in recovery and relapse prevention.

Some study, for example, suggests that certain vitamins, minerals, herbs, and other components may give further advantages in alleviating depression symptoms.

Having said that, herbs and dietary supplements are not subject to the same level of scrutiny as drugs by the Food and Drug Administration (FDA). As a result, you can't always be sure what you're getting and whether it's safe.

Furthermore, additional research is needed to establish which natural supplements are more likely to aid with depression, as well as what adverse effects they may have.

Before incorporating any supplements into your diet, do your homework and consult with your doctor. This article discusses 11 supplements that may be helpful for those who are depressed.

Herbs for depression

 is a herb that has been connected to a number of possible health advantages when used as a supplement. Reduced depressed symptoms and an enhanced stress response might help your body adapt to stressful conditions.

The herb may have antidepressant properties due to its potential to improve nerve cell transmission and diminish hypothalamic-pituitary-adrenocortical (HPA) axis overactivity.

The HPA axis is a complicated mechanism in your body that governs your stress response. According to study, persons who suffer from severe depression may have a hyperactive HPA axis.

Some research suggests that taking rhodiola may help people with depression by changing neurotransmitter receptors and molecular networks, which may improve their mood.

For example, a 12-week therapy with 340 mg of rhodiola extract per day resulted in clinically substantial decreases in depressed symptoms in 57 persons with depression.

Furthermore, while rhodiola therapy was less effective than the antidepressant medicine Sertraline, it was associated with far less negative effects.

Another research discovered that a rhodiola and saffron supplement significantly decreased depression and anxiety symptoms in persons with mild to moderate depression after 6 weeks. Learn more!


Saffron is a vibrantly colored spice high in antioxidant chemicals, such as the carotenoids crocin and crocetin. Saffron, interestingly, has showed potential as a natural cure for depression.

According to research, it raises levels of the mood-boosting chemical serotonin in the brain. While it's unclear how this process works, it's suspected that saffron slows serotonin reuptake, allowing it to stay in the brain for longer.

When compared to placebo treatments, saffron supplementation substantially reduced depressive symptoms in people with MDD, according to a meta-analysis of five randomized controlled studies.

Furthermore, the analysis discovered that saffron supplements were equally efficient as antidepressant drugs in lowering depression symptoms.

The researchers did note, however, that bigger studies with longer follow-up periods were required to adequately test saffron's capacity to help treat depression. Learn more!

Supplements for depression


Omega-3 lipids are essential fats that must be obtained via your diet. According to several research, omega-3 supplements may aid in the treatment of depression.

A 2020 review of 638 women in randomized controlled trials showed that omega-3 fatty acid supplementation significantly alleviated depression symptoms in pregnant and postpartum women.

Supplements having a greater eicosapentaenoic acid (EPA) to docosahexaenoic acid (DHA) ratio were particularly beneficial in the trial. EPA and DHA are two forms of omega-3 fatty acids that are commonly found in seafood.

Another meta-analysis of 26 research with a total of 2,160 individuals discovered that omega-3 supplements had an overall favorable effect on the treatment of depressive symptoms.

Researchers determined that omega-3 formulations with 60% or more EPA in a dosage of 1 gram or less per day were the most beneficial.

While these findings are encouraging, other research have had conflicting results. Omega-3 supplementation did not reduce depressive symptoms in children and adolescents with MDD, according to a 2019 study.

Overall, omega-3 supplements are well accepted and a nutritious complement to your diet if you don't get enough fatty fish. They may also aid in the treatment of depression in some groups. More research, however, is required. Learn more!


NAC is an amino acid precursor to L-cysteine and glutathione. Glutathione is one of your body's most significant antioxidants, and it's essential for controlling inflammation and protecting cells from oxidative damage.

Taking NAC has been demonstrated to provide a variety of health advantages, including increased glutathione levels in the body.

Depressed people had higher levels of inflammatory cytokines such C-reactive protein, interleukin-6, and tumor necrosis factor-alpha, according to study. NAC supplementation may help decrease inflammation and alleviate depressed symptoms.

Furthermore, NAC may help neurotransmitter dysregulation in those suffering from mental diseases. Dysregulation of neurotransmitters such as dopamine and glutamate, among other things, may be linked to mood disorders and schizophrenia.

Finally, a 2016 meta-analysis of five research revealed that NAC therapy substantially decreased depressed symptoms and increased functioning in patients with depression when compared to placebo treatments. Furthermore, the NAC pills were both safe and well tolerated.

Treatment for mental health issues such as depression is recommended at doses of 2–2.4 grams per day. Learn more!

Vitamin D

Vitamin D is an important vitamin that serves a variety of functions in your body. Unfortunately, many people, particularly those suffering from depression, do not have enough vitamin D levels.

According to research, those who suffer from depression are more likely to be vitamin D deficient. Those suffering from the illness have lower vitamin D levels than the general population, and those with the lowest levels have the most severe depression symptoms.

Vitamin D may help battle depression by lowering inflammation, modulating mood, and guarding against neurocognitive impairment.

A 2019 meta-analysis of four randomized controlled studies discovered that vitamin D supplementation resulted in therapeutic improvements in persons suffering from serious depression.

Furthermore, a 2020 study of vitamin D deficient people with depression found that receiving a single 300,000 IU vitamin D injection in addition to their normal medicine significantly improved depressive symptoms, quality of life, and illness severity.

While vitamin D levels are connected to depressive symptoms and supplements may help, more evidence is needed before vitamin D can be recommended as a universal therapy for depression, according to a 2020 review of 61 studies. Learn more!

B vitamins

B vitamins are essential for brain function and mood modulation. B vitamins, such as folate, B12, and B6, are required for the synthesis and control of neurotransmitters such as serotonin, gamma-aminobutyric acid (GABA), and dopamine.

According to research, vitamin B12 and folate deficits may raise the risk of depression, and supplementing with these nutrients may help alleviate depressed symptoms in some populations.

Folate supplements, for example, may be beneficial to children and adults with treatment-resistant depression who have a genetic mutation that prevents folate metabolism.

When taken in conjunction with antidepressant medication, vitamin B12 supplementation has also been found to improve depressive symptoms in persons with MDD.

A 2020 review concluded that taking vitamin B12 supplements early in life may help to postpone the onset of depression and increase the efficacy of antidepressant drugs.

When paired with other nutrients like tryptophan and nicotinamide, a kind of vitamin B3, vitamin B6 has been proven to alleviate depressive symptoms. Learn more!


Zinc is a mineral that is essential for brain health and neurotransmitter pathway control. It contains anti-inflammatory and antioxidant properties as well.

Zinc insufficiency is significantly connected to an increased risk of depression and the severity of depressive symptoms.

One meta-analysis of 17 observational studies found that blood zinc levels in patients with depression were roughly 0.12 g/mL lower than in those without the disease. The study also linked increased zinc deficiency to increased depressed symptoms.

Similarly, a study of four randomized controlled trials showed that when patients took zinc supplements with their antidepressant drugs, their depressed symptoms were dramatically reduced. Learn more!

S-Adenosylmethionine (SAMe)

SAMe is a sulfur-containing chemical that has showed potential in treating depression. It occurs naturally in your body and serves critical functions in brain function.

A analysis of eight research published in 2020 discovered that SAMe, either administered alone or in combination with antidepressant medicines, alleviated depressive symptoms in persons with MDD. The daily dosages varied from 200–3,200 mg, with therapy lasting 2–12 weeks. Learn more!


Magnesium is a vital mineral that may help persons suffering from depression. Magnesium deficiency is common in those who suffer from depression, and research shows that supplementing with the mineral may help them feel better.

In a randomized research of 126 persons with mild to severe depression, consuming 248 mg of magnesium per day for 6 weeks significantly alleviated depressed symptoms when compared to a placebo. Learn more!


Creatine is an organic acid that is essential for preserving brain energy, among other things. Changes in brain energy levels are suggested to have a role in the onset of depression.

Some research suggests that supplementing with 2–10 grams of creatine per day may help patients with MDD. Learn more!

write a comment